What Is SOT?

Supportive Oligonucleotide Therapy (SOT Therapy) goes by many names. It is sometimes called “Short Oligonucleotide Treatment,” “Anti-Sense Oligonucleotide Technique” (AOT), or “Gene-Silencing Therapy.”

“Oligo” means “few” in Greek. A nucleotide is the basic building block of nucleic acid, which forms the backbone of DNA. Oligonucleotides are basically short, single-strand DNA codes. The creation of a specific synthetic oligonucleotide intended to bind to its genetic counterpart in the body is called an “antisense oligonucleotide.”

The first experiment in anti-sense technology took place in 1978. Since then, 6 different anti-sense treatments have been approved by the FDA. In the U.S., Hepatitis C is now cured using an FDA-approved anti-sense technology. Most Hepatitis C patients can be cured with only one treatment, so researchers have high hopes for other diseases as well.

Specifically, supportive oligonucleotide therapy is one form of AOT that has not yet been FDA-approved. However, over the last few years, SOT treatment use has skyrocketed due to the health benefits. SOT works as a cutting-edge, promising new treatment for cancer, Lyme disease, bacterial infections, and certain viral infections such as Herpes and Epstein-Barr virus. Although results cannot be guaranteed, the past few years of clinical experience have shown that symptoms of these diseases can be greatly diminished or eliminated through this treatment plan.

How Does It Work

In layman’s terms, Supportive Oligonucleotide Therapy is the creation of tiny “keys” that precisely fit into chosen “locks” inside the patient’s body, making SOT therapy an individualized therapy. Think of the locks as specific sections of DNA inside each cell that are perpetuating disease. The keys are short sections of information that are designed to fit into each and every lock, breaking apart the information codes that allow for the continuation of that disease.

Inside your body, messenger RNA (mRNA) acts as a go-between, so that your DNA can control protein production. During a process called transcription, mRNA is made in the mirror image of DNA and then leaves the cell wall to be translated into protein. Think of mRNA as the genetic template of DNA, on a mission to carry out DNA’s instructions since DNA is not allowed to leave the nucleus of the cell.

Supportive Oligonucleotide Technique (SOT therapy) works by shutting down gene replication of harmful messenger RNA sequences in cells. What follows is “apoptosis,” or programmed cell death of a cancer cell, viral infections, bacterial infections, or pathogens, destroying their life cycles. Harmful effects of cancer and pathogens are largely due to their rampant growth and activity. SOT treatment prevents gene replication of these unwanted cells, so their numbers steadily shrink over time.

Each SOT therapy molecule attacks a specific target by blocking the expression and transcription of one gene only. After it has done its job, the complementary mRNA then releases the SOT molecule so that it moves on to the next target with the same sequence. Hence, one molecule of SOT can be re-engaged again and again to cause death to thousands of cancer cells, bacterial infections, viral infections, or Lyme disease bacteria.

Each SOT “soldier” is created to be highly specific and will only work for the patient that it was made for; the perfect individualized therapy. Upon injection into the bloodstream, they will break apart each defective sense strand, one by one. (Hence the term “anti-sense.”)

SOT therapy infusions will not interfere with the genetics of human cells. Cell death only affects harmful infections and viruses. SOT is not gene manipulation, gene splicing, or gene insertion. Nor is it technically a drug since the contents of the infusion are created from the patient’s own blood. SOT will not negatively affect a patient’s immune system, nor does it alter his/her DNA, normal organs, tissues, or cells in any way.

This short, 3-minute video on YouTube explains the basic mechanics of how anti-sense treatments work:


Supportive Oligonucleotide Technique (SOT) is effective against Circulating Tumor Cells (CTCs), Cancer Stem Cells (CSCs), Primary Tumor Cells, Human Immunodeficiency Virus (HIV), and Metastatic Tumors.

SOT cannot be used in cases of encapsulated cancers, such as tumors of the brain, due to a lack of circulating cancer cells in the blood. Also, SOT therapy may not be used to treat large or advanced tumors due to a risk of developing Tumor Lysis Syndrome or “TLS.” TLS is a rare occurrence, and the patient is carefully monitored for it to occur.


Supportive Oligonucleotide Therapy (SOT) may be repeated up to three times per year if desired. However, before each new SOT treatment, it is recommended that the patient test again for the presence of circulating tumor cells or pathogens. The goal, of course, is the complete eradication of cancer or infection over time. In the past 5 years, thousands of people have been treated with SOT in the U.S. and around the world with incredible success.

To accurately gauge the body’s response to Supportive Oligonucleotide Therapy (SOT) treatment, a test called “PrimeSpot” is available through RGCCs affiliate lab, Biocentaur, in the United Kingdom. This test is only for patients suffering from Lyme disease or viral infections and cannot be used for cancer patients.

If a patient has multiple active infections, multiple SOT treatments will be needed to treat each separate infection. The response to Supportive Oligonucleotide Therapy (SOT) varies, depending on the overall health of the patient and the severity of his/her condition. Some patients are cured of symptoms in one SOT treatment, and others require two or more treatments to settle into a quiet remission.

There is also a Facebook group of like-minded individuals who have used Supportive Oligonucleotide Therapy (SOT) you may consider joining.

Starting SOT Treatment

If you’re interested in the possibility of trying SOT therapy, book a consultation with Jennifer Baer at our front desk. Jennifer will sit down with you in a one-on-one appointment to review your medical history and most recent test results and answer any questions you may have. She will determine whether you are a good candidate for SOT treatment and order additional labs if necessary.

To begin SOT treatment, one of the nurses at Horizons of Health will do a blood draw and mail the sample to an RGCC lab. Once the lab receives the patient’s blood, RGCC scientists will identify the specific gene sequences that are perpetuating cancer, Lyme disease, or viral infections. Using an international database, they will cross-reference specific gene sequences to create an intravenous infusion that is 98% specific to the patient’s genes. Each infusion is as unique as the patient’s fingerprint.

Replication genes are sometimes called “sense strands.” Sense strands are genetic codes that allow disease-causing pathogens and cells to replicate and invade the body. RGCC creates an “anti-copy” or mirror image of the replication sequences using a sense strand of nucleic acid, which is then surrounded with synthetic messenger RNA so that it has the ability to penetrate cell walls. Anywhere from 500 million to 1 billion copies of the patient’s unique “mirror images” are created. Then, these molecules are packaged and mailed to our office where you will receive them via IV. SOT administration induces rapid apoptosis, which will shut down the gene replication sequences of the target cancer cells and, therefore, eliminate the next lifecycle of the pathogens.

The life span of the oligonucleotides is boosted by a proprietary technique, which makes them unrecognizable to the human enzymes that normally break down oligonucleotides. RGCC has found a way to preserve the solubility of the oligonucleotides as well as their ability to penetrate cell membranes. RGCC’s SOT molecules are hardy and travel everywhere in the body, including through the patient’s blood/brain barrier.

SOT IV Infusion

SOT treatment can be administered as an IV, and works up to six months in the body. Conventional treatment strategies of intravenous antihistamines (Famotidine) and low-dose steroids (Dexamethasone) will be given just before the SOT IV treatment plan begins. These medications help to lessen the already very rare chance of an allergic reaction and to tighten the vein walls, respectively.

The IV takes a little over two hours, during which time you can relax in our infusion room and text or read a book. We ask that you remain in the clinic for 20 minutes or so after you receive your SOT treatment infusion, to make sure you don’t feel dizzy, have body aches, or are lightheaded after receiving your infusion.

You should plan to be at Horizons of Health for about two and a half hours on the day you receive your treatment.

Once the IV infusion is circulating in the bloodstream, SOT treatment molecules will continue fighting the cancer, Lyme disease, or viral infections 24 hours a day, 7 days a week for 3 to 8 months, depending on the individual.

SOT causes only harmful pathogens and cells to die but has no effect on healthy cells and a normal microbiome. SOT molecules are so small that the immune system is unable to detect them.

They circulate quietly throughout the body for many months, destroying only their viral or bacterial targets.


What Types Of Conditions Can Be Treated With SOT?

Many Viruses, including:

Oxygen Icon Box

Oral Herpes Virus (HHV1/HSV1)

Oxygen Icon Box

Genital Herpes Virus (HHV2/HSV2)

Oxygen Icon Box

Human Herpes Virus 6 – Types A & B (HHV6)

Oxygen Icon Box

Cytomegalovirus (CMV)

Oxygen Icon Box

Coxsackie Virus – Types A & B

Oxygen Icon Box

Varicella-Zoster Virus (VZV) also known as Shingles or Chicken Pox

Oxygen Icon Box

Epstein Barr Virus (EBV)

Oxygen Icon Box

Human Papillomaviruses (HPV6, HPV11, HPV16 and HPV18)

Oxygen Icon Box

Hepatitis B (HBV) & Hepatitis C (HCV)

Oxygen Icon Box

Human T-Cell Lymphotropic Virus (HTLV1)

Tick-Borne Illnesses

Supportive Oligonucleotide Technique (SOT therapy) is highly effective against tick-borne illnesses such as Lyme disease. Once Lyme bacteria enter your bloodstream, Lyme bacteria can infect your entire system. Currently, SOT treatment is available for the following Lyme disease Species and Co-Infections:

Oxygen Icon Box

Borrelia Bavariensis, Miyamotoi, Valaisiana, Afzelii, 
Finlandensis, Recurrentis

Oxygen Icon Box

Borrelia Mayonii, Burgdorferi, Garinii, Bissettii, Bissettii

Oxygen Icon Box

Candidatus Borrelia Tachyglossi

Oxygen Icon Box

Bartonella Henselae, Bacilliformis, Vinsonii, Quintana

Oxygen Icon Box

Babesia Microti, Bigemina, Divergens, Duncani

Side Effects

Usually, side effects on gene silencing therapies are minimal. Some patients experience mild bruising, swelling, or tenderness from the IV needle, which subsides within a day or two.

Longer and more systemic side effects often occur because SOT causes cancer cells and other pathogens to die. This “apoptosis,” also known as cell death, can lead to a Herx-Heimer reaction.

The Herx-Heimer reaction, often referred to as "herxing," occurs when toxins from dying bacteria or pathogens are released faster than the body can handle them, leading to temporary exacerbation of symptoms.

The patient may feel sluggish, achy, nauseous, and/or run a temperature (generally less than 101˚F) due to a large number of dead or dying pathogens in the body.

Headaches, body aches, exhaustion, diarrhea, mild cough, or other flu-like symptoms are normal and a sign that the SOT treatment is working.

These side effects typically last anywhere from two days to two weeks. Some patients may feel worse for up to a month after SOT, but almost all have reported a tremendous “payoff” after the uncomfortable symptoms resolved.

More serious risks of SOT infusion can occur in cancer patients who have large tumor burdens. Malignant cell death can produce a large amount of dead cellular debris, which can lead to a condition known as Tumor Lysis Syndrome. (This condition is a risk for patients undergoing chemotherapy and radiation as well.) Dying cells release large amounts of potassium, phosphate, and uric acid into the blood.

This can cause heart or kidney problems only in extreme cases. Supportive Oligonucleotide Technique (SOT therapy) is a healing protocol that can be used in conjunction with all other therapies, except for chemotherapy and radiation.

Rest assured, you will be carefully monitored and evaluated throughout your treatment at Horizons of Health to address any adverse effects that may occur.

TLS is a rare occurrence, and the patient is carefully monitored for it to occur.

If Tumor Lysis Syndrome (TLS) is a risk, a smaller or weaker dose of SOT therapy can be given to be sure that the patient will tolerate treatment.

TLS is not an issue for those using SOT to heal infections from Lyme disease or other viral infections.

Is SOT Covered By Insurance?

A SOT injection will be given during your visit to Horizons of Health, so if your current health plan covers visits to this office, a small percentage of the total cost of SOT may be covered. Please first check with your provider.

Some inclusive health plans allow coverage that can be applied to naturopathic treatments.

We recommend contacting your insurance provider directly prior to finding out if a portion of the cost may be covered.

If you are in Albany, NY, or nearby regions and are interested in SOT treatment, contact us to start the transformative journey toward improved health and vitality.

At Horizons of Health, we are committed to helping you unlock your body's incredible self-healing potential so feel free to set up a call to learn about our programs and other therapies to help you meet your health goals.


Take The First Step Today On Your

Journey Back To Health

Do you have questions about starting your path back to health? Our patient coordinator is standing by, happy to answer any questions you have to determine if our approach is right for you.

Register As A New Patient

About Horizons of Health

Known for her successful approach towards chronic wellness issues, Jennifer Baer, Nurse Practitioner and her team at Horizons of Health combine an integrative, functional medicine approach.

Our unique approach to diagnosing and resolving chronic health issues recognizes that lasting health depends on resolving the root causes of your symptoms. Click here to learn more »

Your Next Steps

After you have reviewed the information on our website and in our downloadable guides, we’d love to hear from you – to answer more specific questions about our approach and track record.

Simply register to become a new patient by calling us at (518) 755-6870 or via our online New Patient Registration Form.

Areas Served

​Horizons of Health is located in Clifton Park, New York, and serves patients throughout Albany County, Schenactady County and Saratoga County including Ballston Lake, Ballston Spa, Saratoga Springs, Glens Falls, Amsterdam, Schenactady, and Albany.
Call Now Button linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram